Protection by natural IgG: a sweet partnership with soluble lectins does the trick!
نویسندگان
چکیده
Irene Puga and Andrea Cerutti* IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona Biomedical Research Park, Barcelona, Spain, Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA and ICREA, Catalan Institute for Research and Advanced Studies, Barcelona Biomedical Research Park, Barcelona, Spain. *Correspondence to: [email protected] or [email protected]
منابع مشابه
Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin
A sweet water-soluble protein that reminds stable over wide ranges of temperature and pH, Brazzein has various applications. Its tastes like cane sugar but have no calories. However, the extraction of brazzein from its natural source is expensive and not applicable. In this study we used recombinant DNA technology to provide an alternative option for cheaper mass production of brazzein. A brazz...
متن کاملNatural IgG antibodies provide innate protection against ficolin-opsonized bacteria.
For nearly five decades since its discovery, the role of natural IgG, which pre-exists in neonates and uninfected individuals, has remained unclear due to the general perception that natural antibodies lack affinity for pathogens. Here, we show for the first time that natural IgG recognizes a spectrum of bacteria through lectins like ficolin and mannose binding lectin (MBL). Infection-inflammat...
متن کاملInvestigating contact toxicity of Geranium and Artemisia essential oils on Bemisia tabaci Gen.
Objective: Sweet potato whitefly, Bemisia tabaci Gen. (B. tabaci), is one of the most important pests of various greenhouse crops in Iran. Nowadays, chemical insecticides are broadly used for control of the pests that causes risk to consumer's health. For the first time, contact toxicity of Pelargonium roseum Andrews and Artemisia sieberi Besser essential oils on B. tabaci and its possible appl...
متن کاملSphingomyelin Liposomes Containing Soluble Leishmania major antigens Induced Strong Th2 Immune Response in BALB/c Mice
Objective(s): Soluble Leishmania antigens (SLA) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. Liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-A (PLA) activity of SLA is a drawback to prepare a stable liposomal SLA. One strategy to overcome this problem migh...
متن کاملDoes BCG vaccine induced trained immunity provide cross-protection against COVID-19?
During the global COVID-19 pandemic, the rate of mortality and morbidity was fairly low in Pakistan compared to western countries. Bacille Calmette-Guerin (BCG) vaccination provides cross-protection for a broad range of related and unrelated pathogens. This protection is attributed to the recognition of broadly cross-reactive Pathogen-Associated Molecular Pattern (PAMPS) like molecules. We inve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The EMBO journal
دوره 32 22 شماره
صفحات -
تاریخ انتشار 2013